Description

2-(Chloromethyl)-4-Fluoro-1-Methoxybenzene is a versatile fluorinated aromatic building block of significant importance in advanced organic synthesis. Its molecular structure, featuring both a reactive chloromethyl group and a fluorine substituent on a methoxybenzene scaffold, makes it a critical intermediate for constructing complex molecules. This compound is essential for research and development chemists and process engineers in the pharmaceutical and agrochemical industries, where it is used to introduce key pharmacophores and structural motifs into active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring fluorinated aromatic systems for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the fluorine atom can improve pesticidal activity and environmental profile.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated aromatic compounds used in electronic displays and organic light-emitting diodes.
• Functional Polymer Monomer: Employed to incorporate reactive sites and fluorine functionality into specialty polymers for high-performance materials.
• Cross-Coupling Reactions: Acts as a substrate in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.
• Chemical Research & Development: A valuable reagent for medicinal chemistry and process chemistry research in both academic and industrial settings.

Basic Information

Product Name	2-(Chloromethyl)-4-Fluoro-1-Methoxybenzene
CAS No.	19415-40-8
Molecular Formula	C8H8ClFO
Molecular Weight	174.60 g/mol
Synonyms	4-Fluoro-2-(chloromethyl)anisole; 1-Chloromethyl-4-fluoro-2-methoxybenzene; 2-Methoxy-5-fluorobenzyl chloride; 5-Fluoro-2-methoxybenzyl chloride; 4-Fluoro-2-methoxybenzyl chloride; (4-Fluoro-2-methoxyphenyl)methyl chloride; Benzene, 2-(chloromethyl)-4-fluoro-1-methoxy-; 2-(Chloromethyl)-4-fluoroanisole
EINECS	Contact for details

Quality Control

Our 2-(Chloromethyl)-4-Fluoro-1-Methoxybenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.