Description

Tosyl Cyanide is a versatile and highly reactive organic synthesis intermediate, primarily used as a cyanation reagent. Its core value proposition lies in its ability to efficiently introduce the nitrile functional group under mild conditions, which is a critical transformation in the synthesis of pharmaceuticals and agrochemicals. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and fine chemical industries who require reliable and high-purity building blocks for complex molecule assembly.

Application

• Pharmaceutical Intermediate: Key reagent in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing cyano groups into heterocyclic and aromatic systems.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and insecticides where the nitrile moiety is a crucial structural component.
• Fine Chemical Production: Serves as a building block for dyes, pigments, and other specialty chemicals requiring nitrile functionality.
• Cross-Coupling Reactions: Acts as a cyanide source in palladium-catalyzed cyanation reactions of aryl halides.
• Nitrile Rubber Modification: Potential use in the modification and synthesis of specialty polymers.
• Research & Development: A valuable tool for medicinal chemistry and process research in academic and industrial laboratories.

Basic Information

Product Name	Tosyl Cyanide
CAS No.	19158-51-1
Molecular Formula	C8H7NO2S
Molecular Weight	181.21 g/mol
Synonyms	p-Toluenesulfonyl Cyanide; 4-Methylbenzenesulfonyl Cyanide; Tosyl Cyanide; TosCN; TsCN; p-Tolylsulfonyl Cyanide; Toluene-4-sulfonyl Cyanide; 4-Toluenesulfonyl Cyanide
EINECS	242-852-1

Quality Control

Our Tosyl Cyanide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, ensuring full traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	52 - 56 °C
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.