Description

Dl-Erythro Ritalinic Acid Hydrochloride is a key chiral intermediate and the primary metabolite of the psychostimulant methylphenidate. Its significance lies in its critical role in pharmaceutical research and development, particularly for studying drug metabolism, pharmacokinetics, and for use as a reference standard. This compound is essential for analytical laboratories, R&D departments, and manufacturers in the pharmaceutical and fine chemical industries focused on central nervous system (CNS) active substances.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the qualitative and quantitative analysis of methylphenidate and its metabolites in drug testing and bioanalytical studies.
• Metabolite Research: Serves as a critical tool in preclinical and clinical research to understand the metabolic pathways, bioavailability, and excretion profiles of methylphenidate-based therapeutics.
• Active Pharmaceutical Ingredient (API) Synthesis: Acts as a chiral building block or intermediate in the synthetic pathways for developing novel CNS-targeting pharmaceuticals or for process chemistry optimization.
• Forensic Analysis: Employed in forensic toxicology laboratories as a standard for the accurate identification and quantification of ritalinic acid in biological specimens.
• Quality Control & Method Development: Essential for developing and validating analytical methods (e.g., HPLC, LC-MS) in pharmaceutical QC labs to ensure product purity and consistency.

Basic Information

Product Name	Dl-Erythro Ritalinic Acid Hydrochloride
CAS No.	19130-92-8
Molecular Formula	C14H19NO2 • HCl
Molecular Weight	269.77 g/mol (Free base: 233.31 g/mol)
Synonyms	α-Phenyl-2-piperidineacetic acid hydrochloride; DL-threo-Methylphenidate acid hydrochloride; Ritalinic acid HCl; (±)-erythro-Ritalinic acid hydrochloride; Methylphenidate metabolite; 2-Piperidineacetic acid, α-phenyl-, hydrochloride, (±)-threo-; α-Phenyl-2-piperidineacetic acid, hydrochloride, DL-threo-
EINECS	Contact for details

Quality Control

Our Dl-Erythro Ritalinic Acid Hydrochloride is produced and tested under a strict quality management system. Each batch undergoes comprehensive analytical testing to ensure high purity and consistency, meeting the rigorous standards required for research and pharmaceutical applications. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.