Description

(2R,3R,4R,5S)-6-Methylaminohexane-1,2,3,4,5-Pentol, 2-[2,4,6-Triiodo-3 ,5-Bis(Methylcarbamoyl)Phenoxy]Octanoic Acid is a high-purity iodinated organic compound, primarily recognized as a key intermediate in the synthesis of advanced X-ray contrast media. Its precise stereochemistry and functional groups are critical for achieving the desired pharmacokinetic properties and imaging efficacy in final pharmaceutical formulations. This compound is essential for manufacturers and research institutions developing next-generation diagnostic agents for vascular and organ imaging.

Application

• Pharmaceutical Intermediate: Primary use as a critical building block in the synthesis of non-ionic, iodinated X-ray contrast agents.
• Diagnostic Imaging Research: Used in R&D for developing novel contrast media with improved safety profiles and imaging clarity.
• Chemical Synthesis: Serves as a versatile intermediate for creating specialized iodinated aromatic compounds for various applications.
• Reference Standard: Employed as a high-purity analytical standard for quality control and method validation in pharmaceutical manufacturing.

Basic Information

Product Name	(2R,3R,4R,5S)-6-Methylaminohexane-1,2,3,4,5-Pentol, 2-[2,4,6-Triiodo-3 ,5-Bis(Methylcarbamoyl)Phenoxy]Octanoic Acid
CAS No.	19080-51-4
Molecular Formula	C₂₃H₃₄I₃N₃O₉
Molecular Weight	897.24 g/mol
Synonyms	Iopamidol Intermediate; Iopamidol Related Compound; 2-[2,4,6-Triiodo-3,5-bis(methylcarbamoyl)phenoxy]octanoic acid derivative; (2R,3R,4R,5S)-6-(Methylamino)hexane-1,2,3,4,5-pentol 2-(2,4,6-triiodo-3,5-bis(methylcarbamoyl)phenoxy)octanoate; Iodinated contrast media precursor; Niopam intermediate; Isovue intermediate
EINECS	Contact for details

Quality Control

Our production of this advanced pharmaceutical intermediate adheres to strict cGMP guidelines to ensure batch-to-batch consistency and traceability. Quality is verified through a comprehensive suite of analytical techniques including HPLC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and impurity profiles against stringent in-house specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its light-sensitive and easily oxidized nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep the container tightly sealed to minimize exposure to moisture and air.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 10 ppm
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.