Description

4-o-Tetrahydropyranyl-4-Hydroxyphenylacetonitrile is a key protected intermediate in advanced organic synthesis, valued for its role in constructing complex molecular architectures. Its primary commercial significance lies in enabling the controlled introduction of functional groups, particularly in the synthesis of pharmaceuticals and fine chemicals. This compound is essential for R&D and production chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking high-purity building blocks for active ingredient development.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds requiring protected phenol functionalities.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides, fungicides, and plant growth regulators.
• Fine Chemical Production: Serves as a versatile precursor for dyes, pigments, and performance chemicals where specific aromatic nitrile chemistry is required.
• Material Science Research: Employed in the development of novel polymers, liquid crystals, and organic electronic materials.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic chemistry and process optimization studies.

Basic Information

Product Name	4-o-Tetrahydropyranyl-4-Hydroxyphenylacetonitrile
CAS No.	19001-09-3
Molecular Formula	C₁₄H₁₇NO₂
Molecular Weight	231.29 g/mol
Synonyms	4-(Tetrahydro-2H-pyran-2-yloxy)phenylacetonitrile; 2-[4-(Oxan-2-yloxy)phenyl]acetonitrile; 4-(Tetrahydropyran-2-yloxy)benzyl cyanide; 4-(THP-Oxy)phenylacetonitrile; 4-Hydroxyphenylacetonitrile tetrahydropyranyl ether; 4-O-THP-4-hydroxyphenylacetonitrile; THP-protected 4-hydroxyphenylacetonitrile; p-(Tetrahydro-2-pyranyloxy)phenylacetonitrile
EINECS	Contact for details

Quality Control

Our 4-o-Tetrahydropyranyl-4-Hydroxyphenylacetonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by FT-IR and NMR, to ensure it meets exacting standards for synthetic applications. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability and consistency for your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from strong oxidizing agents, strong acids, and strong bases. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.