Description

S-Acetoacetylcoenzyme A is a crucial biochemical cofactor and metabolic intermediate essential for lipid biosynthesis and ketone body metabolism. Its primary value lies in enabling critical enzymatic reactions in both research and industrial biocatalysis, serving as a key substrate for HMG-CoA synthase. This high-purity compound is indispensable for pharmaceutical R&D, academic biochemistry studies, and the development of enzymatic assays for metabolic pathway analysis.

Application

• Biochemical Research & Enzyme Studies: Essential substrate for investigating the mevalonate pathway, HMG-CoA synthesis, and ketogenesis.
• Pharmaceutical Development: Used in the research and production of statins and other cholesterol-lowering agents that target HMG-CoA reductase.
• Diagnostic Reagent Manufacturing: A key component in enzymatic assay kits for measuring metabolic enzyme activity (e.g., HMG-CoA synthase, thiolase).
• Metabolomics & Systems Biology: Serves as a standard and tracer in metabolic flux analysis to study lipid metabolism.
• Industrial Biocatalysis: Employed as a co-substrate in enzymatic synthesis for producing fine chemicals and chiral intermediates.
• Academic Teaching: Used in advanced biochemistry laboratories to demonstrate coenzyme A-dependent enzymatic mechanisms.

Basic Information

Product Name	S-Acetoacetylcoenzyme A
CAS No.	1420-36-6
Molecular Formula	C25H40N7O19P3S
Molecular Weight	851.60 g/mol
Synonyms	Acetoacetyl-CoA; S-Acetoacetyl-CoA; Acetoacetyl Coenzyme A; 3-Oxobutanoyl-CoA; 3-Oxobutyryl-CoA; AcAc-CoA; Coenzyme A, S-acetoacetyl-
EINECS	215-817-7

Quality Control

Our S-Acetoacetylcoenzyme A is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and enzymatic activity assays to ensure biological functionality. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to guarantee compliance with research and process development standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term stability, store desiccated. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Enzymatic Activity	≥ 90% (vs. reference standard)
Water Content (KF)	≤ 5.0 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.