Description

Carbobenzyloxy-L-Phenylalanyl-L-Norvaline Methyl Ester is a protected dipeptide derivative, specifically a benzyloxycarbonyl (Cbz)-protected L-Phenylalanyl-L-Norvaline methyl ester. This compound serves as a crucial building block in the synthesis of complex peptides and peptidomimetics, offering controlled reactivity for sequential coupling strategies. It is primarily utilized by pharmaceutical researchers and fine chemical manufacturers engaged in the development of therapeutic peptides, protease inhibitors, and other bioactive molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled, stepwise assembly of longer peptide chains.
• Pharmaceutical Research: Building block for the development of novel peptide-based drugs and active pharmaceutical ingredients (APIs).
• Protease Inhibitor Development: Used in the synthesis of substrates and inhibitors for enzymes like renin and other aspartic proteases.
• Bioconjugation: Serves as a starting material for creating peptide conjugates for diagnostic or targeted delivery applications.
• Chemical Biology: Employed in the study of protein-protein interactions and signal transduction pathways.
• Fine Chemical Synthesis: Intermediate for custom peptide synthesis services and catalog chemical production.

Basic Information

Product Name	Carbobenzyloxy-L-Phenylalanyl-L-Norvaline Methyl Ester
CAS No.	18921-55-6
Molecular Formula	C24H30N2O5
Molecular Weight	426.51 g/mol
Synonyms	Z-Phe-Nva-OMe; Cbz-Phe-Nva-OMe; Nα-Carbobenzyloxy-L-phenylalanyl-L-norvaline methyl ester; Benzyl N-[(2S)-1-[[(2S)-1-methoxy-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamate; Z-L-Phenylalanyl-L-norvaline methyl ester; Cbz-L-Phe-L-Nva-OMe; N-Carbobenzyloxy-L-phenylalanyl-L-norvaline methyl ester
EINECS	Contact for details

Quality Control

Our Carbobenzyloxy-L-Phenylalanyl-L-Norvaline Methyl Ester is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral analysis to ensure enantiomeric integrity, meeting the exacting standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Optical Rotation [α]D20	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.