Description

Pimeloyl-Coenzyme A is a crucial biochemical intermediate, specifically a thioester derivative of pimelic acid and coenzyme A. This compound is essential for research and development in metabolic pathways, particularly in the biosynthesis of biotin (vitamin B7). It is primarily utilized by biochemists, pharmaceutical researchers, and life science companies engaged in enzyme kinetics studies, metabolic engineering, and the development of novel therapeutic agents.

Application

• Enzymology Research: Critical substrate for studying the activity and kinetics of enzymes involved in biotin biosynthesis, such as BioF (7-keto-8-aminopelargonic acid synthase).
• Metabolic Pathway Analysis: Used as a tracer or standard in analytical methods (e.g., LC-MS) to investigate and quantify metabolic fluxes in microbial or cellular systems.
• Pharmaceutical Development: Serves as a key intermediate in research targeting antibacterial agents, as the biotin pathway is essential for many pathogens but absent in humans.
• Industrial Biotechnology: Applied in metabolic engineering of microbial strains (e.g., E. coli, yeast) for the enhanced fermentative production of biotin and related compounds.
• Diagnostic Reagent Manufacturing: Used in the formulation of specialized assay kits for measuring enzyme activities or metabolic disorders related to coenzyme A metabolism.
• Academic Research: Fundamental tool for university and institutional labs studying fatty acid metabolism, cofactor biology, and one-carbon metabolism.

Basic Information

Product Name	Pimeloyl-Coenzyme A
CAS No.	18907-20-5
Molecular Formula	C28H46N7O19P3S
Molecular Weight	933.68 g/mol
Synonyms	Pimeloyl-CoA; Pimeloyl Coenzyme A; Coenzyme A, S-pimeloyl-; Pimeloyl-coenzyme A lithium salt; 7-KAP Synthase Substrate; Biotin Biosynthesis Intermediate; S-Pimeloylcoenzyme A; Pimeloyl-CoA trisodium salt
EINECS	Contact for details

Quality Control

Our Pimeloyl-Coenzyme A is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity and identity confirmation (NMR, MS). We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. For specific purity requirements (e.g., >95%, >98%), please contact our technical team.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated under an inert atmosphere. Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder or lyophilized solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 90%
Water Content (KF)	≤ 5.0 %
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.