Description

Ethyl α-Cyano-4-Fluorocinnamate is a high-purity fluorinated cinnamate derivative, serving as a critical synthetic intermediate in advanced organic chemistry. This compound is valued for its role in constructing complex molecular architectures, particularly in the synthesis of biologically active molecules. It is essential for research and development laboratories and production facilities in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate fluorinated motifs into their target compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated drug candidates, including potential kinase inhibitors and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the research and development of novel fluorinated pesticides and herbicides, where the fluorine atom can enhance bioavailability and stability.
• Material Science Research: Serves as a monomer or precursor in the development of advanced polymers and liquid crystals with tailored optical or electronic properties.
• Organic Synthesis: A versatile reagent for Knoevenagel condensation reactions and other C-C bond-forming processes to create α-cyanoacrylates and other functionalized structures.
• Fluorine Chemistry Studies: An important substrate for investigating the effects of fluorine substitution on reaction pathways and molecular properties in academic and industrial R&D.

Basic Information

Product Name	Ethyl α-Cyano-4-Fluorocinnamate
CAS No.	18861-57-9
Molecular Formula	C₁₂H₁₀FNO₂
Molecular Weight	219.21 g/mol
Synonyms	Ethyl (2Z)-2-Cyano-3-(4-fluorophenyl)prop-2-enoate; Ethyl (Z)-2-Cyano-3-(4-fluorophenyl)acrylate; 4-Fluorobenzylidenecyanoacetic Acid Ethyl Ester; (Z)-Ethyl 2-Cyano-3-(4-fluorophenyl)acrylate; Ethyl (Z)-α-Cyano-4-fluorocinnamate; 2-Propenoic acid, 2-cyano-3-(4-fluorophenyl)-, ethyl ester, (Z)-; NSC 334365; Ethyl 2-cyano-3-(4-fluorophenyl)-2-propenoate
EINECS	Contact for details

Quality Control

Our Ethyl α-Cyano-4-Fluorocinnamate is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity verification and NMR/IR for structural confirmation, to ensure it meets the high standards required for research and industrial synthesis. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat sources and incompatible materials. The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.