Description

Methyl 3,3,3-trifluoropropionate is a versatile fluorinated ester building block of significant commercial interest. Its value lies in its trifluoromethyl group, which imparts unique physicochemical properties such as enhanced metabolic stability and lipophilicity, making it a critical intermediate in advanced synthesis. This compound is essential for R&D and production within the pharmaceutical, agrochemical, and specialty materials sectors, where the introduction of fluorine atoms is a key design strategy.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) containing trifluoromethyl motifs, particularly in antiviral and anticancer drug discovery.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the CF₃ group improves biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display technologies and organic light-emitting diodes (OLEDs).
• Polymer & Resin Modification: Employed to introduce fluorine into polymer chains, enhancing properties like chemical resistance, thermal stability, and surface characteristics.
• Organic Synthesis Reagent: A valuable reagent for nucleophilic trifluoromethylation and other fluorination reactions in complex molecule construction.
• Specialty Solvents & Additives: Used in formulations requiring specific solvation power or as an additive to alter surface tension and volatility profiles.

Basic Information

Product Name	Methyl 3,3,3-Trifluoropropionate
CAS No.	18830-44-9
Molecular Formula	C₄H₅F₃O₂
Molecular Weight	142.08 g/mol
Synonyms	3,3,3-Trifluoropropionic Acid Methyl Ester; Methyl β,β,β-Trifluoropropionate; Trifluoropropionic Acid Methyl Ester; MTP; Methyl Trifluoropropanoate; 3,3,3-Trifluoropropanoic Acid Methyl Ester; Propanoic acid, 3,3,3-trifluoro-, methyl ester
EINECS	242-606-6

Quality Control

Our Methyl 3,3,3-trifluoropropionate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, NMR, and Karl Fischer titration, to ensure it meets the high-purity standards required for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials such as strong acids, bases, and oxidizing agents. Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use to prevent evaporation and maintain product integrity. Recommended storage temperature: 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.320 - 1.340
Density (20°C)	1.25 - 1.30 g/mL
Related Substances (GC)	Individual impurity ≤ 1.0%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.