Description

Boc-Gln-Osu CAS NO 18800-78-7 is a protected amino acid derivative, specifically N-α-(tert-Butoxycarbonyl)-L-glutamine N-hydroxysuccinimide ester. This compound is a critical reagent in peptide synthesis, offering a stable and reactive intermediate for the efficient coupling of glutamine residues while protecting the amine functionality. It is primarily required by research institutions, pharmaceutical development labs, and fine chemical manufacturers engaged in the production of peptides, peptidomimetics, and bioactive compounds.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key building block for the controlled incorporation of glutamine into peptide chains, preventing side reactions.
• Solution-Phase Peptide Synthesis: Used in classical coupling reactions for constructing specific peptide sequences in solution.
• Pharmaceutical Intermediate: Serves as a crucial precursor in the research and development of therapeutic peptides and protein-based drugs.
• Bioconjugation: Facilitates the site-specific labeling or modification of proteins, antibodies, and other biomolecules with glutamine-containing tags.
• Chemical Biology Research: Employed in the synthesis of probes, inhibitors, and tools for studying enzyme function and protein-protein interactions.
• Production of Custom Peptides: Essential for CROs (Contract Research Organizations) and CDMOs (Contract Development and Manufacturing Organizations) offering bespoke peptide services.

Basic Information

Product Name	Boc-Gln-Osu
CAS No.	18800-78-7
Molecular Formula	C14H21N3O7
Molecular Weight	343.33 g/mol
Synonyms	N-α-(tert-Butoxycarbonyl)-L-glutamine N-hydroxysuccinimide ester; Boc-L-glutamine N-succinimidyl ester; Boc-Gln-OSu; Boc-Gln-ONSu; (S)-2-((tert-Butoxycarbonyl)amino)-5-((2,5-dioxopyrrolidin-1-yl)oxy)-5-oxopentanoic acid; N-(tert-Butoxycarbonyl)glutamine N-hydroxysuccinimide ester; N-Boc-L-glutamine acid N-hydroxysuccinimide ester
EINECS	Contact for details

Quality Control

Our Boc-Gln-Osu is manufactured under strict quality systems to ensure batch-to-batch consistency and high chemical purity, suitable for sensitive research and development applications. All products undergo rigorous analytical testing, including HPLC for purity and chiral integrity. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Optical Rotation [α]20/D	-15.0° to -18.0° (c=1 in DMF)
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.