Description

4,6,8-Trichloro-2-(Trifluoromethyl)Quinoline is a halogenated quinoline derivative that serves as a versatile and high-value synthetic intermediate. Its unique molecular structure, featuring both chlorine and trifluoromethyl substituents, makes it a critical building block for the development of advanced functional materials and active pharmaceutical ingredients. This compound is primarily sought by research and development teams in the pharmaceutical, agrochemical, and specialty chemical sectors for creating novel compounds with targeted properties.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the research and development of next-generation pesticides, herbicides, and fungicides, leveraging the bioactivity of the quinoline core.
• Material Science Research: Serves as a building block for organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, due to its electron-deficient quinoline structure.
• Ligand and Catalyst Development: Utilized in organometallic chemistry to create novel ligands and catalysts for asymmetric synthesis and cross-coupling reactions.
• Fluorinated Compound Library: An essential scaffold for medicinal chemistry and combinatorial chemistry to build libraries of fluorinated compounds for high-throughput screening.
• Dye and Pigment Intermediate: Potential intermediate in the synthesis of specialized dyes, pigments, and photographic chemicals.

Basic Information

Product Name	4,6,8-Trichloro-2-(Trifluoromethyl)Quinoline
CAS No.	18706-37-1
Molecular Formula	C10H3Cl3F3N
Molecular Weight	289.49 g/mol
Synonyms	2-(Trifluoromethyl)-4,6,8-trichloroquinoline; 4,6,8-Trichloro-2-trifluoromethylquinoline; Quinoline, 4,6,8-trichloro-2-(trifluoromethyl)-; 18706-37-1; 4,6,8-Trichloro-2-(trifluoromethyl)chinolin; 4,6,8-Trichloro-2-trifluoromethyl-chinolin
EINECS	Contact for details

Quality Control

Our 4,6,8-Trichloro-2-(trifluoromethyl)quinoline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring reliability for your most demanding R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.