Description

L-Histidine, Methyl Ester, Monohydrochloride is a protected derivative of the essential amino acid L-Histidine, where the carboxylic acid group is esterified and the compound is stabilized as a hydrochloride salt. This modification enhances its stability and solubility profile, making it a crucial building block for advanced peptide synthesis and biochemical research. It is primarily utilized by pharmaceutical R&D teams, peptide manufacturers, and academic laboratories engaged in developing bioactive peptides, enzyme inhibitors, and novel therapeutic agents.

Application

• Peptide Synthesis: A key protected amino acid derivative for solid-phase and solution-phase peptide synthesis (SPPS), particularly in sequences requiring the unique properties of the histidine side chain.
• Pharmaceutical Intermediates: Serves as a critical intermediate in the research and development of peptide-based drugs, including hormone analogs and enzyme inhibitors.
• Biochemical Research: Used in studies of enzyme mechanisms, receptor-ligand interactions, and as a standard in analytical method development for amino acid analysis.
• Protecting Group Strategy: The methyl ester group provides a common protecting strategy for the C-terminus during multi-step organic and peptide synthesis.

Basic Information

Product Name	L-Histidine, Methyl Ester, Monohydrochloride
CAS No.	18684-16-7
Molecular Formula	C7H12N3O2 • HCl
Molecular Weight	215.65 g/mol
Synonyms	L-Histidine Methyl Ester Hydrochloride; Histidine Methyl Ester HCl; Methyl L-Histidinate Hydrochloride; (S)-2-Amino-3-(1H-imidazol-4-yl)propanoic Acid Methyl Ester Hydrochloride; H-His-OMe • HCl; Fmoc-His(Trt)-OH related building block precursor; CAS 18684-16-7
EINECS	Contact for details

Quality Control

Our L-Histidine, Methyl Ester, Monohydrochloride is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the exacting standards required for pharmaceutical research and peptide synthesis. Certificates of Analysis (COA) with detailed HPLC, NMR, and optical rotation data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	[α]²⁰D: +10.0° to +15.0° (c=1 in H₂O)
Chiral Purity	≥99.0% (L-isomer)
Loss on Drying	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.