Description

2-Bromo-3-Butyne is a versatile halogenated alkyne building block, essential for advanced organic synthesis. Its high reactivity, particularly in Sonogashira and other cross-coupling reactions, makes it a critical intermediate for constructing complex molecular architectures. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries to introduce functionalized alkyne groups.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and novel drug candidates, especially those requiring alkyne functionalization.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and plant growth regulators that incorporate acetylene motifs.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers, conductive materials, and metal-organic frameworks (MOFs).
• Organic Synthesis Reagent: Employed in Sonogashira, Heck, and other palladium-catalyzed cross-coupling reactions to form carbon-carbon bonds.
• Ligand & Catalyst Preparation: Useful for synthesizing specialized ligands and organometallic catalysts used in homogeneous catalysis.
• Chemical Biology Probes: Acts as a precursor for click chemistry reagents and bio-conjugation tools used in proteomics and diagnostics.

Basic Information

Product Name	2-Bromo-3-Butyne
CAS No.	18668-72-9
Molecular Formula	C4H5Br
Molecular Weight	132.99 g/mol
Synonyms	3-Butyn-2-yl Bromide; 1-Bromo-2-butyne; 2-Butynyl Bromide; Bromobut-2-yne; 2-Butyne, 2-bromo-; 2-Bromo-2-butyne; 2-Bromobut-2-yne; Bromo-2-butyne
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-3-Butyne is produced and tested under strict quality management protocols to ensure consistency and purity for sensitive synthetic applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing purity, identity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated place, away from heat, sparks, and open flame. Due to its highly volatile nature, keep container tightly sealed when not in use. Recommended storage temperature is 2-8°C (refrigerated) for extended stability. Keep away from incompatible materials such as strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Density (at 20°C)	~1.45 g/mL
Boiling Point	~110-115°C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.