Description

Boc-Glu(Otbu)-Ome CAS NO 18635-51-3 is a protected amino acid derivative, specifically the tert-butyl ester of N-Boc-L-glutamic acid 5-methyl ester, serving as a crucial building block in peptide synthesis. Its primary value lies in providing orthogonal protection for the glutamic acid side chain, enabling precise and complex peptide chain assembly. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors developing novel therapeutic peptides and protein-based drugs.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected intermediate for the controlled incorporation of glutamic acid residues.
• Solution-Phase Peptide Synthesis: Used in the synthesis of complex peptides and small proteins where selective deprotection is required.
• Pharmaceutical Intermediates: Serves as a critical raw material in the research and production of active pharmaceutical ingredients (APIs) for peptide therapeutics.
• Bioconjugation and Labeling: The protected carboxylic acid group can be used for further functionalization or conjugation with other molecules.
• Chemical Biology Research: Employed in the study of protein-protein interactions and the development of enzyme inhibitors or probes.
• Custom Peptide Service Providers: A standard reagent for CROs and CDMOs offering bespoke peptide manufacturing.

Basic Information

Product Name	Boc-Glu(Otbu)-Ome
CAS No.	18635-51-3
Molecular Formula	C15H27NO6
Molecular Weight	317.38 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-L-glutamic acid 5-tert-butyl 1-methyl ester; Boc-L-glutamic acid 5-tert-butyl ester 1-methyl ester; (S)-2-((tert-Butoxycarbonyl)amino)pentanedioic acid 1-methyl 5-tert-butyl ester; Boc-Glu(OtBu)-OMe; Boc-Glu(OtBu)-OMe; N-Boc-L-glutamic acid α-methyl γ-tert-butyl ester; L-Glutamic acid, N-[(1,1-dimethylethoxy)carbonyl]-, 1-methyl 5-(1,1-dimethylethyl) ester
EINECS	Contact for details

Quality Control

Our Boc-Glu(Otbu)-Ome is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic identification, to ensure it meets the high standards required for sensitive peptide synthesis. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, ensuring traceability and batch-to-batch consistency for your critical research and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Optical Rotation [α]	Specific range provided on COA
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.