Description

2-Chloro-3,5-Difluoroanisole is a versatile halogenated anisole derivative that serves as a critical building block in advanced organic synthesis. Its value lies in the strategic positioning of chlorine and fluorine atoms on the aromatic ring, enabling precise structural modifications for high-value intermediates. This compound is essential for R&D and production chemists in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules, particularly those requiring difluorinated aromatic systems for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of modern pesticides and herbicides, where the chloro and fluoro substituents contribute to biological activity and environmental persistence.
• Liquid Crystal Materials: Serves as a building block for fluorinated liquid crystal compounds used in display technologies.
• Organic Electronic Materials: Employed in the research and production of materials for organic light-emitting diodes (OLEDs) and semiconductors.
• Chemical Research & Development: A valuable reagent for exploring new coupling reactions and synthesizing novel fluorinated aromatic compounds in academic and industrial labs.
• Fine Chemical Production: Utilized in custom synthesis and contract manufacturing for specialized chemical products.

Basic Information

Product Name	2-Chloro-3,5-Difluoroanisole
CAS No.	18627-23-1
Molecular Formula	C7H5ClF2O
Molecular Weight	178.56 g/mol
Synonyms	1-Chloro-2,4-difluoro-5-methoxybenzene; Benzene, 1-chloro-2,4-difluoro-5-methoxy-; 2,4-Difluoro-5-methoxychlorobenzene; 5-Methoxy-2,4-difluorochlorobenzene; 2-Chloro-3,5-difluorophenyl methyl ether; Anisole, 2-chloro-3,5-difluoro-; 3,5-Difluoro-2-chloroanisole
EINECS	Contact for details

Quality Control

Our 2-Chloro-3,5-Difluoroanisole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including GC/HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for synthetic applications. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases. Recommended storage temperature is between 15°C and 25°C. Keep container tightly sealed when not in use to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Density (at 20°C)	~1.4 g/cm³

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.