Description

Methyl L-Isoleucinate Hydrochloride is a high-purity, protected amino acid derivative essential for advanced peptide synthesis and pharmaceutical research. This compound serves as a critical chiral building block, enabling the precise construction of complex bioactive molecules. It is primarily utilized by research institutions, pharmaceutical developers, and fine chemical manufacturers focused on creating novel therapeutic peptides, peptidomimetics, and other specialized organic compounds.

Application

• Peptide Synthesis: A key chiral intermediate in solid-phase and solution-phase peptide synthesis (SPPS) for incorporating the L-isoleucine residue.
• Pharmaceutical Research: Used in the development and scale-up of active pharmaceutical ingredients (APIs) for metabolic and hormonal therapies.
• Biochemical Research: Employed in enzymatic studies and as a substrate analog for investigating amino acid metabolism and transport.
• Fine Chemical Production: Serves as a versatile building block for synthesizing more complex, non-natural amino acid derivatives and specialty chemicals.
• Protecting Group Strategy: The methyl ester group provides a protected carboxyl function, allowing for selective deprotection and further functionalization in multi-step syntheses.

Basic Information

Product Name	Methyl L-Isoleucinate Hydrochloride
CAS No.	18598-74-8
Molecular Formula	C7H16ClNO2
Molecular Weight	181.66 g/mol
Synonyms	L-Isoleucine methyl ester hydrochloride; Methyl (2S,3S)-2-amino-3-methylpentanoate hydrochloride; (2S,3S)-2-Amino-3-methylpentanoic acid methyl ester hydrochloride; H-Ile-OMe·HCl; Isoleucine methyl ester HCl; Methyl L-2-amino-3-methylvalerate hydrochloride; L-Isoleucine methyl ester HCl salt
EINECS	Contact for details

Quality Control

Our Methyl L-Isoleucinate Hydrochloride is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical research and peptide synthesis. A Certificate of Analysis (COA) detailing identity, purity, and specific impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Specific Rotation [α]20/D	+20.0° to +25.0° (c=1 in H2O)
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals (as Pb)	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.