Description

Cob(I)Alamin CAS NO 18534-66-2 is a highly reactive, reduced form of vitamin B12, also known as vitamin B12s, which serves as a critical intermediate in biological cobalamin metabolism. This compound is essential for research and development in biochemistry and pharmaceutical synthesis, particularly for studying enzymatic mechanisms and creating novel B12 derivatives. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on advanced cofactor chemistry and metabolic pathway analysis.

Application

• Biochemical Research: As a key intermediate for studying the mechanisms of B12-dependent enzymes such as methionine synthase and methylmalonyl-CoA mutase.
• Pharmaceutical Synthesis: A crucial precursor in the synthesis of various cobalamin analogs and labeled B12 compounds for diagnostic and therapeutic applications.
• Enzymology Studies: Used in vitro to investigate one-carbon transfer reactions and radical-based rearrangements catalyzed by cobalamin.
• Nutritional Science Research: Employed in metabolic studies to understand the absorption, transport, and intracellular processing of vitamin B12.
• Reference Standard: Serves as a high-purity analytical standard for HPLC and LC-MS methods in quantifying B12 vitamers in complex matrices.
• Catalysis Development: Exploration of its potential as a bio-inspired catalyst in organic synthesis for selective methyl group transfers.

Basic Information

Product Name	Cob(I)Alamin
CAS No.	18534-66-2
Molecular Formula	C62H89CoN13O14P
Molecular Weight	1348.34 g/mol
Synonyms	Vitamin B12s; B12s; Cob(I)alamin; Cobalt(I)alamin; Reduced Vitamin B12; Supernucleophilic B12; Co(I)alamin; CoIcobalamin
EINECS	Contact for details

Quality Control

Our Cob(I)Alamin is produced and handled under stringent conditions to ensure the integrity of this sensitive compound. Each batch is analyzed to confirm identity, purity, and stability, with comprehensive testing including HPLC for assay and related substances. A Certificate of Analysis (COA) documenting all critical parameters is provided with every shipment to support your research and quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from all light exposure. For long-term stability, store under an inert atmosphere (e.g., argon or nitrogen) at 2-8°C. This product is strictly light-sensitive and easily oxidized; exposure to air, light, or elevated temperatures will lead to rapid degradation.

Specification

Item	Specification
Appearance	Red to reddish-brown solid
Identification (HPLC)	Conforms to reference standard
Identification (UV-Vis)	Spectrum matches characteristic profile
Assay (HPLC)	≥ 95.0%
Total Impurities (HPLC)	≤ 5.0%
Solubility	Soluble in water, methanol; insoluble in non-polar organic solvents

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.