Description

(4-Chlorophenylthio)Acetonitrile is a versatile sulfur-containing nitrile building block, essential for advanced organic synthesis. Its unique structure, featuring both a chlorophenylthio group and a reactive nitrile moiety, makes it a critical intermediate for constructing complex molecules with tailored properties. This high-purity compound is primarily sought by research and development chemists and process engineers in the pharmaceutical, agrochemical, and material science industries for applications ranging from drug discovery to polymer modification.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing thioether or heterocyclic structures.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging the bioactivity of the chlorophenylthio group.
• Material Science: Serves as a monomer or cross-linking agent in the production of specialty polymers, resins, and liquid crystals.
• Organic Synthesis Building Block: Employed in palladium-catalyzed cross-coupling reactions, nucleophilic substitutions, and cyanoethylation processes to introduce functional complexity.
• Ligand and Catalyst Development: Useful for synthesizing novel sulfur- and nitrogen-containing ligands for metal complexes used in catalysis.
• Research & Development: A valuable reagent for medicinal chemistry and chemical biology research in academic and industrial laboratories.

Basic Information

Item	Details
Product Name	(4-Chlorophenylthio)Acetonitrile
CAS No.	18527-19-0
Molecular Formula	C8H6ClNS
Molecular Weight	183.66 g/mol
Synonyms	2-[(4-Chlorophenyl)thio]acetonitrile; 4-Chlorophenylthiocyanomethane; p-Chlorophenylthioacetonitrile; (p-Chlorophenylthio)acetonitrile; 4-Chlorobenzenethioacetonitrile; 1-Chloro-4-(cyanomethylthio)benzene; α-[(4-Chlorophenyl)thio]acetonitrile
EINECS	Contact for details

Quality Control

Our (4-Chlorophenylthio)Acetonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in opaque packaging or amber glass.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.