Description

n-(tert-Butoxycarbonyl)-p-Toluenesulfonamide is a high-purity chemical intermediate featuring a protected sulfonamide group. This compound matters for its critical role in the synthesis of complex molecules, particularly in pharmaceutical research and development, where it serves as a versatile building block. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing active pharmaceutical ingredients (APIs) and other specialty compounds.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of novel drug candidates and active pharmaceutical ingredients (APIs).
• Peptide Chemistry: Used in the protection of sulfonamide groups during solid-phase and solution-phase peptide synthesis.
• Agrochemical Synthesis: Serves as a precursor in the development of advanced herbicides, fungicides, and pesticides.
• Fine Chemical Production: Employed in the manufacture of complex specialty chemicals, dyes, and functional materials.
• Academic & Industrial R&D: A valuable reagent for method development and exploring new synthetic pathways in organic chemistry laboratories.
• Protecting Group Strategy: The tert-butoxycarbonyl (Boc) group provides orthogonal protection, enabling selective reactions in complex molecular architectures.

Basic Information

Product Name	n-(tert-Butoxycarbonyl)-p-Toluenesulfonamide
CAS No.	18303-04-3
Molecular Formula	C12H17NO4S
Molecular Weight	271.33 g/mol
Synonyms	N-Boc-4-methylbenzenesulfonamide; 4-Methyl-N-[(2-methyl-2-propanyl)oxy]carbonyl]benzenesulfonamide; tert-Butyl p-toluenesulfonylcarbamate; N-(tert-Butoxycarbonyl)-4-methylbenzenesulfonamide; N-Boc-p-toluenesulfonamide; Boc-Tos-NH2; Tosylcarbamic acid tert-butyl ester; p-Toluenesulfonamide, N-[(1,1-dimethylethoxy)carbonyl]-
EINECS	Contact for details

Quality Control

Our n-(tert-Butoxycarbonyl)-p-Toluenesulfonamide is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and consistency for critical R&D and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed in a dry environment. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	108 - 112 °C
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.