Description

10,11-Dihydro-5-[3-(4-Methyl-1-Piperazinyl)-1-Oxopropyl]-5H-Dibenz[B,F]Azepine is a high-purity pharmaceutical intermediate and research chemical of significant commercial interest. This compound matters for its role as a key precursor in the synthesis of complex active pharmaceutical ingredients (APIs), particularly within the central nervous system (CNS) therapeutic area. Pharmaceutical manufacturers and advanced research organizations need this material for its structural complexity and potential in developing new therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of tricyclic dibenzazepine-based active pharmaceutical ingredients (APIs).
• Neurological Research: Used in preclinical and clinical research for developing novel compounds targeting CNS disorders.
• Chemical Synthesis: Serves as a versatile scaffold for medicinal chemists to create new molecular entities through further functionalization.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and impurity profiling.
• Process Development: Utilized in optimizing and scaling up synthetic routes for commercial pharmaceutical production.

Basic Information

Product Name	10,11-Dihydro-5-[3-(4-Methyl-1-Piperazinyl)-1-Oxopropyl]-5H-Dibenz[B,F]Azepine
CAS No.	18300-61-3
Molecular Formula	C22H27N3O
Molecular Weight	349.47 g/mol
Synonyms	5-[3-(4-Methylpiperazin-1-yl)propanoyl]-10,11-dihydro-5H-dibenzo[b,f]azepine; Desmethylclozapine; Norclozapine; N-Desmethylclozapine; 1-(3-(10,11-Dihydro-5H-dibenzo[b,f]azepin-5-yl)-3-oxopropyl)-4-methylpiperazine; Clozapine Impurity A; Clozapine Metabolite
EINECS	Contact for details

Quality Control

Our 10,11-Dihydro-5-[3-(4-Methyl-1-Piperazinyl)-1-Oxopropyl]-5H-Dibenz[B,F]Azepine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider inert atmosphere conditions to ensure stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.