Description

(Trimethylsilyl)Acetonitrile is a versatile organosilicon reagent featuring a reactive nitrile group protected by a trimethylsilyl moiety. This compound is critical for introducing the cyano functional group in advanced synthetic sequences, particularly where standard conditions are incompatible. It is an essential building block for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors seeking to develop novel compounds and functional polymers.

Application

• Pharmaceutical Intermediate: Key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing cyano groups in complex molecules.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and insecticides that require a protected cyanomethyl unit.
• Organometallic Chemistry: Serves as a precursor for generating reactive carbanions and in the preparation of silicon-containing ligands.
• Polymer & Material Science: A monomer or modifying agent for creating specialty silicones, cyano-functionalized polymers, and advanced composite materials.
• Cross-Coupling Reactions: Employed in palladium-catalyzed reactions, such as cyanation processes, to construct biaryl systems.
• Nucleoside & Peptide Modification: Used to introduce cyanoethyl or related protecting groups in the synthesis of modified biomolecules.

Basic Information

Product Name	(Trimethylsilyl)Acetonitrile
CAS No.	18293-53-3
Molecular Formula	C5H11NSi
Molecular Weight	113.23 g/mol
Synonyms	Trimethylsilylacetonitrile; (Trimethylsilyl)ethanenitrile; Acetonitrile, (trimethylsilyl)-; TMSCN (common abbreviation); NSC 163944; 2-(Trimethylsilyl)acetonitrile; Cyanomethyltrimethylsilane; Silane, (cyanomethyl)trimethyl-
EINECS	Contact for details

Quality Control

Our (Trimethylsilyl)Acetonitrile is produced under stringent quality management systems. Every batch undergoes comprehensive analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications and supporting your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and incompatible materials. The container must be kept tightly sealed due to moisture sensitivity and potential volatility.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.