Description

o-T-Butyl-L-Tyrosine is a protected derivative of the essential amino acid L-tyrosine, featuring a tert-butyl group on the phenolic oxygen. This modification is critical for its primary role as a key chiral building block in the synthesis of complex peptides and active pharmaceutical ingredients (APIs). It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require high-purity, stereochemically defined intermediates for drug discovery and development processes.

Application

• Pharmaceutical Intermediate: A crucial building block for the solid-phase and solution-phase synthesis of therapeutic peptides and peptidomimetics.
• API Synthesis: Used in the research and commercial production of Active Pharmaceutical Ingredients (APIs) that incorporate modified tyrosine residues.
• Bioconjugation & Probe Development: Serves as a precursor for creating labeled compounds, imaging agents, and biochemical probes due to its reactive phenolic group (when deprotected).
• Academic & Industrial Research: Employed in medicinal chemistry for structure-activity relationship (SAR) studies and the development of novel bioactive compounds.
• Custom Peptide Services: A standard reagent for contract research and manufacturing organizations (CROs/CMOs) offering bespoke peptide synthesis.

Basic Information

Product Name	o-T-Butyl-L-Tyrosine
CAS No.	18222-59-8
Molecular Formula	C₁₃H₁₉NO₃
Molecular Weight	237.29 g/mol
Synonyms	O-tert-Butyl-L-tyrosine; (2S)-2-Amino-3-[4-[(2-methylpropan-2-yl)oxy]phenyl]propanoic acid; L-Tyrosine, O-(1,1-dimethylethyl)-; Boc-Tyr(tBu)-OH (common abbreviation when used with Boc protection); Fmoc-Tyr(tBu)-OH (common abbreviation when used with Fmoc protection); H-Tyr(tBu)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-tert-butyl-L-tyrosine
EINECS	Contact for details

Quality Control

Our o-T-Butyl-L-Tyrosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical research and development. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, detailing parameters such as chiral purity, chemical purity, and residual solvents.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is kept sealed in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.