Description

Metopimazine Sulfoxide is a key pharmaceutical intermediate and metabolite of the antiemetic agent metopimazine. This compound matters for its critical role in the research, development, and quality control of neuroleptic and anti-nausea medications. It is primarily needed by pharmaceutical R&D laboratories, analytical testing facilities, and manufacturers of active pharmaceutical ingredients (APIs) for use in synthesis, reference standards, and impurity profiling.

Application

• Pharmaceutical Intermediate: Used in the synthesis and process development of metopimazine and related therapeutic agents.
• Analytical Reference Standard: Serves as a certified standard for HPLC, LC-MS, and other chromatographic methods in quality control laboratories.
• Metabolite Studies: Employed in pharmacokinetic and drug metabolism research to understand the biotransformation pathways of metopimazine.
• Impurity Characterization: Critical for identifying and quantifying process-related impurities and degradation products in metopimazine API batches.
• Research Chemical: Utilized in preclinical and pharmacological studies to investigate the structure-activity relationships of phenothiazine derivatives.

Basic Information

Product Name	Metopimazine Sulfoxide
CAS No.	18181-99-2
Molecular Formula	C₂₂H₂₈N₄O₂S
Molecular Weight	412.55 g/mol
Synonyms	Metopimazine S-Oxide; Metopimazine Sulfone (common misnomer); 1-[(10H-Phenothiazin-10-yl)methyl]-4-(2-methoxyphenyl)piperazine 5-Oxide; Vogalene Sulfoxide; Vogalene Metabolite; 18181-99-2; 10-[(4-(2-Methoxyphenyl)-1-piperazinyl)methyl]phenothiazine 5-oxide
EINECS	Contact for details

Quality Control

Our Metopimazine Sulfoxide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identity confirmation by spectroscopic methods (IR, NMR) and purity determination by HPLC to ensure it meets stringent specifications for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting batch-specific results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.