Description

3,21-Dihydroxypregna-3,5-Dien-20-One Bis(Heptafluorobutyrate) is a high-purity, fluorinated steroid derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical synthetic intermediate or analytical reference standard for the development of novel steroid-based therapeutics. It is primarily utilized by research institutions, pharmaceutical companies, and contract development and manufacturing organizations (CDMOs) engaged in steroid chemistry. The precise functionalization with heptafluorobutyrate groups makes it a valuable tool for probing metabolic pathways and developing targeted bioactive molecules.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of complex steroid-based active pharmaceutical ingredients (APIs).
• Analytical Reference Standard: Used for method development, validation, and quality control (QC) in HPLC, LC-MS, and GC-MS analysis of steroid compounds.
• Metabolic Studies: Employed as a probe or precursor in research investigating steroid metabolism, biotransformation, and pharmacokinetics.
• Biochemical Research: Serves as a ligand or modulator in studies targeting steroid hormone receptors and related enzymatic pathways.
• Process Development: Used in scaling up and optimizing synthetic routes for steroid derivatives within GMP environments.

Basic Information

Product Name	3,21-Dihydroxypregna-3,5-Dien-20-One Bis(Heptafluorobutyrate)
CAS No.	18072-34-9
Molecular Formula	C31H32F14O6
Molecular Weight	742.57 g/mol
Synonyms	3,21-Dihydroxypregna-3,5-dien-20-one bis(heptafluorobutyrate); 3β,21-Dihydroxypregna-5,7-dien-20-one 3,21-bis(heptafluorobutyrate); Pregna-3,5-diene-3,21-diol-20-one bis(heptafluorobutyrate); 3,21-Bis(O-heptafluorobutyryl)pregna-3,5-dien-20-one; Heptafluorobutyric acid 3,21-dihydroxypregna-3,5-dien-20-one diester
EINECS	Contact for details

Quality Control

Our 3,21-Dihydroxypregna-3,5-Dien-20-One Bis(Heptafluorobutyrate) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or development specifications. Our quality commitment supports applications requiring high-purity reference materials and intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. This material is light-sensitive (store away from light). For long-term storage, consider inert atmosphere conditions to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.