Description

Nα,1-Bis(Trimethylsilyl)-L-Histidine Trimethylsilyl Ester is a key silylated derivative of the essential amino acid L-histidine, designed to enhance reactivity and stability in sensitive synthetic processes. This compound is critical for protecting functional groups and facilitating peptide synthesis, particularly in the preparation of complex biomolecules where standard coupling reagents may be insufficient. It serves as a vital building block for researchers and manufacturers in pharmaceutical development, advanced organic synthesis, and proteomics research, enabling the creation of novel peptides and histidine-modified compounds.

Application

• Peptide Synthesis: Used as a protected histidine derivative in solid-phase and solution-phase peptide synthesis (SPPS) to prevent side reactions and improve coupling yields.
• Pharmaceutical Intermediates: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates that incorporate histidine or imidazole motifs.
• Bioconjugation & Labeling: Facilitates the site-specific modification of peptides and proteins for diagnostic and therapeutic applications.
• Organometallic & Catalysis Research: Serves as a ligand precursor or a modifying agent in the development of novel metal complexes and catalysts.
• Proteomics & Biochemical Research: Employed in the study of enzyme mechanisms, histidine-tagged protein interactions, and metabolic pathway analysis.
• Advanced Material Science: Used in the synthesis of functionalized polymers and biomimetic materials that require precise amino acid incorporation.

Basic Information

Product Name	Nα,1-Bis(Trimethylsilyl)-L-Histidine Trimethylsilyl Ester
CAS No.	17908-25-7
Molecular Formula	C15H33N3O2Si3
Molecular Weight	371.70 g/mol
Synonyms	L-Histidine, Nα,1-bis(trimethylsilyl)-, trimethylsilyl ester; Histidine TMS derivative; Nα,Nim-Bis(trimethylsilyl)-L-histidine trimethylsilyl ester; Silylated L-Histidine; TMS-Histidine-OTMS; (S)-2-((Bis(trimethylsilyl)amino)-3-(1-(trimethylsilyl)-1H-imidazol-4-yl)propanoate; Protected Histidine Derivative; 17908-25-7
EINECS	Contact for details

Quality Control

Our Nα,1-Bis(Trimethylsilyl)-L-Histidine Trimethylsilyl Ester is manufactured under controlled conditions to ensure high purity and batch-to-batch consistency suitable for research and cGMP applications. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at temperatures between 2°C and 8°C (refrigerated) or as specified on the label. Due to its highly volatile and hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation and moisture uptake. Keep away from heat and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.