Description

Boc-L-Isoleucine Methyl Ester is a protected amino acid derivative of significant importance in organic synthesis. This compound serves as a crucial chiral building block for the controlled construction of peptides and peptidomimetics. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical industries for developing active pharmaceutical ingredients (APIs) and complex bioactive molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the sequential addition of L-isoleucine residues under standard Boc-protection strategies.
• Solution-Phase Peptide Synthesis: Used in the synthesis of short to medium-length peptide sequences in solution.
• Pharmaceutical Intermediate: Critical for the research and production of peptide-based drugs and therapeutic agents.
• Bioconjugation & Labeling: Acts as a precursor for introducing the isoleucine moiety into larger biomolecules or for creating labeled compounds.
• Combinatorial Chemistry: Employed in libraries for drug discovery and structure-activity relationship (SAR) studies.
• Fine Chemical Synthesis: Used as a chiral synthon in the asymmetric synthesis of non-peptide compounds requiring the (2S,3S)-2-amino-3-methylpentanoic acid structure.

Basic Information

Product Name	Boc-L-Isoleucine Methyl Ester
CAS No.	17901-01-8
Molecular Formula	C12H23NO4
Molecular Weight	245.32 g/mol
Synonyms	(2S,3S)-2-[(tert-Butoxycarbonyl)amino]-3-methylpentanoic acid methyl ester; Methyl (2S,3S)-2-[(tert-butoxycarbonyl)amino]-3-methylpentanoate; N-(tert-Butoxycarbonyl)-L-isoleucine methyl ester; N-Boc-L-isoleucine methyl ester; Boc-Ile-OMe; Nα-Boc-L-isoleucine methyl ester; tert-Butyloxycarbonyl-L-isoleucine methyl ester
EINECS	Contact for details

Quality Control

Our Boc-L-Isoleucine Methyl Ester is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation by IR and NMR spectroscopy. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or cGMP manufacturing requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Specific Rotation [α]D20	Contact for details
Melting Point	Contact for details
Heavy Metals	<10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.