Description

7-Hydroxywarfarin is a key hydroxylated metabolite of the anticoagulant drug warfarin, identified by CAS NO 17834-03-6. This compound is of significant importance in pharmaceutical research and development, particularly for studying warfarin's metabolic pathways, pharmacokinetics, and drug-drug interactions. It serves as a critical reference standard and intermediate for researchers and manufacturers in the pharmaceutical, analytical chemistry, and life science sectors who require high-purity materials for method development, bioanalysis, and impurity profiling.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantitative and qualitative analysis of warfarin and its metabolites in biological matrices via HPLC, LC-MS, or GC-MS.
• Metabolite Research: Essential for in vitro and in vivo studies investigating the metabolism, clearance, and enzymatic pathways (primarily CYP450) of warfarin.
• Impurity Standard: Employed in the identification and control of process-related impurities and degradation products during the manufacturing and quality control of warfarin API (Active Pharmaceutical Ingredient).
• Clinical Toxicology: Applied in forensic and clinical toxicology labs to confirm warfarin exposure and understand poisoning cases.
• Biochemical Assay Development: Utilized as a substrate or inhibitor in enzymatic assays to study the activity of specific cytochrome P450 isoforms.
• Academic Research: Serves as a tool compound in universities and research institutes for pharmacological and metabolic studies related to anticoagulant therapies.

Basic Information

Product Name	7-Hydroxywarfarin
CAS No.	17834-03-6
Molecular Formula	C19H16O6
Molecular Weight	340.33 g/mol
Synonyms	7-Hydroxywarfarin; 4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one; Warfarin, 7-hydroxy-; 3-(α-Acetonylbenzyl)-4-hydroxycoumarin, 7-hydroxy derivative; 7-Hydroxy-3-(α-phenyl-β-acetylethyl)-4-hydroxycoumarin; 7-OH Warfarin; 7-Hydroxycoumarin warfarin analog
EINECS	Contact for details

Quality Control

Our 7-Hydroxywarfarin is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including identification (IR, NMR), purity assay (HPLC), and control of related substances, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) providing batch-specific data is supplied with every order to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.