Description

n-Nitrosodimethyl-D6-Amine is a deuterium-labeled isotopologue of the well-known nitrosamine compound, N-nitrosodimethylamine (NDMA). This stable isotope-labeled standard is critical for ensuring analytical accuracy and traceability in modern laboratory analysis. It is primarily utilized by analytical chemists and researchers in pharmaceutical, environmental, and food safety sectors who require precise quantification of nitrosamine impurities. The compound serves as an essential reference material for method development, validation, and high-precision quantification.

Application

• Internal Standard for Mass Spectrometry (MS): Essential for quantitative analysis using GC-MS or LC-MS/MS, correcting for instrument variability and sample preparation losses.
• Pharmaceutical Impurity Testing: Used in the accurate quantification of genotoxic nitrosamine impurities (e.g., NDMA) in active pharmaceutical ingredients (APIs) and finished drug products to comply with regulatory limits (e.g., FDA, EMA).
• Environmental and Food Safety Analysis: Enables precise monitoring of nitrosamine levels in water, air, and food products like cured meats and alcoholic beverages.
• Metabolic and Pharmacokinetic Studies: Acts as a tracer in research investigating the metabolism, distribution, and fate of nitrosamines in biological systems.
• Method Development and Validation: Serves as a key component in establishing robust, sensitive, and specific analytical methods for nitrosamine detection.
• Quality Control and Assurance: Provides a definitive standard for calibrating equipment and verifying the accuracy of in-house testing protocols in quality control laboratories.

Basic Information

Product Name	n-Nitrosodimethyl-D6-Amine
CAS No.	17829-05-9
Molecular Formula	C₂D₆N₂O
Molecular Weight	80.13 g/mol
Synonyms	NDMA-d6; N-Nitrosodimethylamine-d6; Dimethylnitrosamine-d6; N,N-Dimethylnitrosamine-d6; Deuterated NDMA; N-Methyl-N-nitrosomethanamine-d6; (Dimethyl-d6)nitrosamine; Isotopically labeled NDMA
EINECS	Contact for details

Quality Control

Every batch of our n-Nitrosodimethyl-D6-Amine is produced and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, verified by advanced spectroscopic and chromatographic techniques. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing batch-specific data including assay, isotopic enrichment, and impurity profile. Our quality commitment ensures the material meets the stringent requirements for use as a certified reference standard in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C (refrigerated) or as specified on the label or Certificate of Analysis. Due to its highly volatile nature, ensure containers are securely sealed and handled in a well-ventilated area. For long-term storage, keep under inert atmosphere if specified.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity (GC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Solvent (Residual)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.