Description

Ethyl 2-Oxo-2-[3-(Trifluoromethyl)Anilino]Acetate is a high-purity, specialized organic intermediate featuring a reactive α-ketoester moiety linked to a trifluoromethyl-substituted aniline. This compound is valued for its role as a versatile building block in the synthesis of complex molecules, particularly in pharmaceutical and agrochemical research and development. It is primarily sought by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and crop protection industries for constructing novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the development of advanced organic materials, including polymers and liquid crystals with specific electronic or optical properties.
• Custom Synthesis and Contract Manufacturing: A critical component for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client projects.

Basic Information

Product Name	Ethyl 2-Oxo-2-[3-(Trifluoromethyl)Anilino]Acetate
CAS No.	17738-86-2
Molecular Formula	C11H10F3NO3
Molecular Weight	261.20 g/mol
Synonyms	Ethyl (3-Trifluoromethylphenyl)oxamidate; Ethyl N-(3-Trifluoromethylphenyl)oxamate; 2-Oxo-2-[(3-trifluoromethyl)anilino]acetic acid ethyl ester; Ethyl α-oxo-α-[(3-trifluoromethyl)anilino]acetate; Oxamic acid, N-[3-(trifluoromethyl)phenyl]-, ethyl ester; Ethyl 2-[(3-Trifluoromethylphenyl)amino]-2-oxoacetate; Ethyl (3-Trifluoromethylphenyl)oxamate
EINECS	Contact for details

Quality Control

Our production of Ethyl 2-Oxo-2-[3-(Trifluoromethyl)Anilino]Acetate adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is subjected to comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We support cGMP (current Good Manufacturing Practice) standards for pharmaceutical-grade material upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and sources of ignition. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5% w/w

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.