Description

Scopolamine -D-Glucuronide CAS NO 17660-02-5 is a high-purity, chemically defined metabolite of the tropane alkaloid scopolamine. This compound is of critical importance for pharmaceutical research and development, serving as a key reference standard and analytical tool. It is primarily required by analytical laboratories, pharmaceutical manufacturers, and research institutions engaged in drug metabolism studies, pharmacokinetic analysis, and bioanalytical method validation.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantification of scopolamine and its metabolites in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK): Essential for studying the Phase II glucuronidation metabolic pathway of scopolamine in preclinical and clinical research.
• Bioanalytical Method Development: Serves as a critical calibrant and quality control sample in LC-MS/MS and HPLC methods for therapeutic drug monitoring and toxicology.
• Impurity Profiling: Employed in the identification and characterization of process-related impurities or degradation products in scopolamine-based pharmaceutical formulations.
• Clinical Research: Supports studies investigating the pharmacokinetic profile, bioavailability, and excretion mechanisms of scopolamine in human subjects.
• Forensic Toxicology: Acts as a definitive standard for the confirmatory analysis of scopolamine and its metabolites in forensic investigations.

Basic Information

Product Name	Scopolamine -D-Glucuronide
CAS No.	17660-02-5
Molecular Formula	C24H31NO10
Molecular Weight	493.50 g/mol
Synonyms	Scopolamine D-Glucuronide; Scopolamine Glucuronide; (-)-Scopolamine Glucuronide; Scopolamine β-D-Glucuronide; 6β,7β-Epoxy-3α-[(S)-tropoyloxy]tropane D-Glucuronide; Hyoscine Glucuronide; Scopolamine-3α-glucuronide; Tropane-3α-ol, 6,7-epoxy-, (1R,2S,3S,5S)-, ester with (S)-3-hydroxy-2-phenylpropanoic acid, D-glucuronate
EINECS	Contact for details

Quality Control

Our Scopolamine -D-Glucuronide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide a comprehensive Certificate of Analysis (COA) with each shipment, detailing all test results against stringent in-house specifications. Our quality commitment ensures the material's suitability for use as a pharmaceutical reference standard in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the certificate of analysis. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.