Description

(R)-1,1,1-Trifluoro-2-Propanol is a chiral fluorinated alcohol building block of significant importance in advanced organic synthesis. Its value lies in its ability to introduce a trifluoromethyl group and a stereogenic center, which can dramatically influence the biological activity and metabolic stability of target molecules. This high-purity enantiomer is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries developing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring fluorinated motifs for enhanced potency and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the trifluoromethyl group improves efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science: Employed in the creation of specialty polymers and liquid crystals with unique optical and electronic properties.
• Analytical Standard: Used as a high-purity reference standard in chromatographic analysis and method development.

Basic Information

Product Name	(R)-1,1,1-Trifluoro-2-Propanol
CAS No.	17628-73-8
Molecular Formula	C3H5F3O
Molecular Weight	114.07 g/mol
Synonyms	(R)-1,1,1-Trifluoro-2-propanol; (R)-2-Trifluoromethyl ethanol; (R)-Hexafluoroisopropanol enantiomer; (R)-TFIP; (R)-1,1,1-Trifluoro-2-hydroxypropane; (R)-α-(Trifluoromethyl)ethanol; (R)-2-Propanol, 1,1,1-trifluoro-; (R)-TFP
EINECS	Contact for details

Quality Control

Every batch of our (R)-1,1,1-Trifluoro-2-Propanol is produced and tested under strict quality management systems. We guarantee high chemical and enantiomeric purity to meet the demanding requirements of research and cGMP manufacturing. Comprehensive analytical testing, including chiral HPLC/GC, NMR, and Karl Fischer titration, is performed. A Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Due to its highly volatile nature, keep away from heat, sparks, and open flame. Ensure containers are kept tightly sealed when not in use to prevent evaporation and moisture absorption.

Specification

Item	Specification
Appearance	Colorless clear liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.