Description

(S)-1,1,1-Trifluoro-2-Propanol is a high-value, chiral fluorinated alcohol serving as a critical building block in advanced organic synthesis. Its unique stereochemistry and trifluoromethyl group make it indispensable for introducing chirality and fluorine atoms into target molecules, significantly altering their physical, chemical, and biological properties. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty materials sectors who require enantiomerically pure intermediates for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs), particularly in antiviral, anticancer, and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the production of advanced, optically active pesticides and herbicides where the specific stereochemistry enhances efficacy and reduces environmental impact.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis, enabling highly selective chemical transformations.
• Advanced Material Research: Employed in the development of specialty polymers, liquid crystals, and fluorinated materials with tailored properties like chemical resistance and thermal stability.
• Analytical Chemistry: Utilized as a derivatization agent or a chiral resolving agent in chromatographic methods for enantiomeric separation and analysis.

Basic Information

Product Name	(S)-1,1,1-Trifluoro-2-Propanol
CAS No.	17556-48-8
Molecular Formula	C3H5F3O
Molecular Weight	114.07 g/mol
Synonyms	(S)-1,1,1-Trifluoropropan-2-ol; (S)-2-Trifluoromethyl ethanol; (S)-TFPO; (S)-α-Trifluoromethyl ethanol; (S)-1,1,1-Trifluoro-2-hydroxypropane; (S)-2-Hydroxy-1,1,1-trifluoropropane; (S)-TFP; (S)-(−)-1,1,1-Trifluoro-2-propanol
EINECS	Contact for details

Quality Control

Our (S)-1,1,1-Trifluoro-2-Propanol is produced under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity. Quality is verified through comprehensive analytical techniques including chiral HPLC, GC, NMR, and optical rotation measurement. A Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles is provided with each shipment to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials such as strong acids, bases, and oxidizing agents. Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use to prevent evaporation and concentration changes. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (GC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Optical Rotation [α]D20	-10.0° to -12.0° (c=1, MeOH)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.