Description

Z-Asp(Otbu)-Onp is a protected aspartic acid derivative, specifically an active ester, used as a key building block in peptide synthesis. This compound is critical for researchers and manufacturers requiring high-purity intermediates to ensure the fidelity and yield of complex peptide sequences. It is primarily utilized by the pharmaceutical, biotechnology, and advanced research sectors for the development of therapeutic peptides, diagnostic agents, and novel biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an activated ester for the controlled incorporation of aspartic acid under mild conditions.
• Solution-Phase Peptide Synthesis: For the segment condensation or stepwise synthesis of peptide fragments in solution.
• Pharmaceutical Intermediate: In the research and production of peptide-based active pharmaceutical ingredients (APIs).
• Bioconjugation: For coupling peptides to other molecules, such as proteins, dyes, or polymers, in drug delivery systems.
• Research & Development: As a specialized reagent in academic and industrial labs for exploring new peptide structures and functions.
• Production of Protected Dipeptides: Serving as a starting material for the synthesis of more complex, side-chain protected peptide intermediates.

Basic Information

Product Name	Z-Asp(Otbu)-Onp
CAS No.	17543-17-8
Molecular Formula	C22H26N2O7
Molecular Weight	430.45 g/mol
Synonyms	N-Cbz-L-aspartic acid 4-tert-butyl ester p-nitrophenyl ester; Z-L-Aspartic acid β-tert-butyl ester α-p-nitrophenyl ester; Z-Asp(OBut)-ONp; Nα-Carbobenzoxy-L-aspartic acid β-tert-butyl ester α-4-nitrophenyl ester; (S)-4-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-5-((tert-butoxy)carbonyl)-5-oxopentanoic acid p-nitrophenyl ester (common mis-assignment check); Benzyl N-[(2S)-4-[(2-methylpropan-2-yl)oxy]-1-[(4-nitrophenoxy)carbonyl]-4-oxobutan-2-yl]carbamate; Fmoc-Asp(OtBu)-ONp (related Fmoc-protected variant).
EINECS	Contact for details

Quality Control

Our Z-Asp(Otbu)-Onp is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation by IR and NMR spectroscopy. Certificates of Analysis (COA) with detailed specifications are provided to ensure compliance with your research and cGMP-grade production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep container tightly sealed in a desiccated environment after opening.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity ([α]D / Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.