Description

n-Phthalimido 4-Nitro-L-Phenylalanine is a protected amino acid derivative, specifically an N-phthaloyl-protected nitro-phenylalanine, serving as a critical chiral building block in advanced organic synthesis. Its value lies in providing a chemically stable, enantiomerically pure intermediate that facilitates the controlled introduction of the 4-nitro-L-phenylalanine moiety into complex target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly for the development of peptide-based drugs, enzyme inhibitors, and other bioactive compounds where precise stereochemistry and functional group manipulation are paramount.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel peptide therapeutics and protease inhibitors.
• Bioconjugation & Probe Development: Used in the preparation of labeled peptides and affinity probes for biochemical and diagnostic research.
• Solid-Phase Peptide Synthesis (SPPS): Serves as a protected amino acid derivative for the controlled assembly of complex peptide sequences.
• Chemical Biology Research: Employed in the study of protein-protein interactions and enzyme mechanisms by incorporating modified amino acids.
• Material Science: Potential monomer for the synthesis of specialized polymers with unique optical or electronic properties.
• Academic & R&D Laboratories: A valuable reagent for methodological development in asymmetric synthesis and medicinal chemistry.

Basic Information

Product Name	n-Phthalimido 4-Nitro-L-Phenylalanine
CAS No.	17451-66-0
Molecular Formula	C17H13N3O6
Molecular Weight	355.30 g/mol
Synonyms	N-[(4-Nitrophenyl)methyl]-L-phenylalanine, N-Phthaloyl-4-nitro-L-phenylalanine; 2-[[(2S)-2-[(4-Nitrophenyl)methyl]-3-phthalimidopropanoyl]amino]acetic acid (related form); 4-Nitro-L-phenylalanine N-phthalimide; N-(4-Nitrobenzyl)-L-phenylalanine N-phthaloyl derivative; Phth-4-NO2-Phe-OH; Fmoc-4-Nitro-L-Phenylalanine (precursor derivative); (S)-2-(1,3-Dioxoisoindolin-2-yl)-3-(4-nitrophenyl)propanoic acid
EINECS	Contact for details

Quality Control

Our n-Phthalimido 4-Nitro-L-Phenylalanine is produced under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We adhere to relevant industry standards for fine chemical manufacturing, and specifications can be tailored to meet specific project requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The compound may be light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.