Description

n-Me-His-Oh Hcl CAS NO 17451-62-6 is a high-purity, protected derivative of the amino acid histidine, specifically N-methyl-L-histidine hydrochloride. This compound serves as a critical building block in advanced pharmaceutical research and peptide synthesis, offering precise control over molecular structure and bioactivity. It is primarily utilized by research institutions, pharmaceutical developers, and fine chemical manufacturers engaged in the creation of novel therapeutic peptides, enzyme inhibitors, and biochemical probes.

Application

• Pharmaceutical Intermediate: A key raw material in the synthesis of complex peptide-based drugs and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) as a protected amino acid derivative to incorporate modified histidine residues.
• Biochemical Research: Employed in studying enzyme mechanisms, receptor-ligand interactions, and as a standard in analytical method development.
• Proteomics & Metabolomics: Serves as a reference compound or an internal standard in mass spectrometry-based analyses.
• Nutraceutical Research: Investigated for its potential role in the development of specialized nutritional supplements and bioactive compounds.

Basic Information

Product Name	n-Me-His-Oh Hcl
CAS No.	17451-62-6
Molecular Formula	C7H12N3O2•HCl
Molecular Weight	207.65 g/mol
Synonyms	N-Methyl-L-histidine hydrochloride; (2S)-2-Amino-3-(1-methyl-1H-imidazol-5-yl)propanoic acid hydrochloride; 1-Methyl-L-histidine HCl; L-1-Methylhistidine hydrochloride; 3-Methyl-L-histidine hydrochloride; Methylhistidine HCl; N(τ)-Methyl-L-histidine hydrochloride
EINECS	Contact for details

Quality Control

Our n-Me-His-Oh Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and residual solvent screening, to ensure it meets the stringent requirements for research and pharmaceutical applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry conditions to prevent degradation. For long-term storage, consider desiccated environments.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	[α]20/D: Specific range available
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.