Description

Cholesterol Glucuronide is a crucial conjugated metabolite of cholesterol, formed via the glucuronidation pathway. This compound serves as a vital biochemical standard and research reagent for studying cholesterol metabolism, detoxification, and transport mechanisms. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and diagnostic manufacturers focused on metabolic and cardiovascular disease research.

Application

• Biochemical Research Standard: Used as a high-purity reference standard in analytical methods (HPLC, LC-MS) for quantifying cholesterol metabolites in biological samples.
• Metabolic Pathway Studies: Essential for investigating the glucuronidation pathway of cholesterol, its role in bile acid synthesis, and overall sterol homeostasis.
• Enzyme Activity Assays: Serves as a specific substrate for studying the activity and kinetics of UDP-glucuronosyltransferase (UGT) enzymes.
• Diagnostic Development: Employed in the development and calibration of diagnostic assays for metabolic disorders and liver function tests.
• Pharmaceutical R&D: Used in drug discovery and development programs targeting cholesterol-related diseases, to understand drug-cholesterol interaction metabolites.
• Cell Culture & In Vitro Studies: Applied in cell-based assays to study the effects of cholesterol conjugates on membrane biology and cellular signaling.

Basic Information

Product Name	Cholesterol Glucuronide
CAS No.	17435-78-8
Molecular Formula	C33H54O8
Molecular Weight	578.78 g/mol
Synonyms	Cholesteryl β-D-Glucopyranosiduronic Acid; 3β-Cholest-5-en-3-yl β-D-Glucopyranosiduronic Acid; Cholesterol D-Glucuronide; Cholesteryl Glucuronide; NSC 401005; Glucuronic acid cholesterol ester
EINECS	Contact for details

Quality Control

Our Cholesterol Glucuronide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture to ensure it meets stringent research-grade specifications. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistency for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation and storage under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.