Description

Benzyloxycarbonyl-3-Aminoglutaric Acid is a protected amino acid derivative, specifically a glutamic acid analog with a benzyloxycarbonyl (Cbz or Z) protecting group on the amine functionality. This compound is a critical building block (synthon) in organic synthesis, particularly for the controlled construction of peptides and other complex molecules. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for drug discovery and development processes.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel active pharmaceutical ingredients (APIs) and peptide-based therapeutics.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to introduce a protected glutamic acid residue, enabling the creation of specific peptide sequences.
• Bioconjugation & Linker Chemistry: Employed in the development of drug-linker systems for antibody-drug conjugates (ADCs) and other targeted delivery platforms.
• Chemical Biology Research: Acts as a tool compound for studying enzyme mechanisms, particularly those involving glutamyl proteases or transferases.
• Protecting Group Strategy: The Cbz group allows for selective amine protection and deprotection during multi-step synthetic routes.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing custom fine chemicals for clients.

Basic Information

Product Name	Benzyloxycarbonyl-3-Aminoglutaric Acid
CAS No.	17336-01-5
Molecular Formula	C₁₃H₁₅NO₆
Molecular Weight	281.26 g/mol
Synonyms	N-Carbobenzoxy-3-aminoglutaric Acid; N-Cbz-3-aminoglutaric Acid; Z-3-Aminoglutaric Acid; (3-Amino-1,5-dioxopentan-2-yl)carbamic acid benzyl ester; 3-[(Benzyloxycarbonyl)amino]pentanedioic acid; 3-(N-Carbobenzyloxyamino)glutaric Acid; 3-[(Cbz-amino)]glutaric Acid; N-(Benzyloxycarbonyl)-L-glutamic acid 1-amide (related isomer)
EINECS	Contact for details

Quality Control

Our Benzyloxycarbonyl-3-Aminoglutaric Acid is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for research and pharmaceutical applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed to prevent absorption of atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.