Description

4,4,4-Trifluoro-3-(Trifluoromethyl)Butyric Acid is a high-value, fluorinated carboxylic acid building block characterized by its unique perfluoroalkyl side chain. This compound matters for its role as a critical intermediate in the synthesis of advanced materials and active pharmaceutical ingredients (APIs), where its fluorine atoms impart desirable properties like enhanced metabolic stability and lipophilicity. It is primarily needed by R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries for developing novel fluorinated compounds.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing fluorinated drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides where fluorine substitution improves efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, enhancing performance and stability.
• Polymer Modification: Incorporates fluorine functionality into polymers to improve chemical resistance, reduce surface energy, and enhance durability.
• Organic Synthesis Reagent: Acts as a versatile reagent for introducing the -CF(CF3)CH2COOH moiety into complex molecules in medicinal and materials chemistry.
• Fluorinated Surfactant Precursor: Used in the development of high-performance surfactants and surface coatings.

Basic Information

Product Name	4,4,4-Trifluoro-3-(Trifluoromethyl)Butyric Acid
CAS No.	17327-33-2
Molecular Formula	C5H4F6O2
Molecular Weight	210.08 g/mol
Synonyms	3-(Trifluoromethyl)-4,4,4-trifluorobutyric Acid; 4,4,4-Trifluoro-3-(trifluoromethyl)butanoic Acid; Butyric acid, 4,4,4-trifluoro-3-(trifluoromethyl)-; Perfluoro-tert-butylacetic Acid; 2H,2H-Perfluoro-3-methylbutyric Acid; 3-(Trifluoromethyl)perfluorobutyric Acid; TFBA (context-specific); Heptafluoroisovaleric Acid (common misnomer, check context)
EINECS	Contact for details

Quality Control

Our 4,4,4-Trifluoro-3-(Trifluoromethyl)Butyric Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR/IR for structural confirmation, to ensure it meets precise customer specifications. Certificates of Analysis (COA) with full traceability are provided for every shipment, supporting compliance in cGMP and ISO 9001 environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases and oxidizing agents. Recommended storage temperature is 2-8°C for long-term stability. The container must be kept tightly sealed due to the compound's nature as a strong acid/organic solvent and to minimize moisture uptake.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20/D)	1.340 - 1.360
Density (g/mL at 25°C)	1.55 - 1.65

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.