Description

Benzyloxycarbonyl-Glycyl-Glycyl-Arginine β-Naphthylamide is a specialized synthetic peptide substrate designed for enzymatic studies. This compound is of significant value in biochemical research and pharmaceutical development as a chromogenic and fluorogenic substrate for the detection and quantification of specific proteolytic enzyme activity. It is primarily utilized by researchers and quality control laboratories in the life sciences, pharmaceutical manufacturing, and diagnostic reagent development sectors.

Application

• Protease Enzyme Assays: Acts as a specific chromogenic/fluorogenic substrate for the detection and kinetic analysis of trypsin-like serine proteases, including thrombin, plasmin, and urokinase.
• Biochemical Research: Used in fundamental research to study enzyme kinetics, inhibition mechanisms, and substrate specificity of various peptidases.
• Pharmaceutical Screening: Employed in high-throughput screening (HTS) platforms to identify and characterize novel protease inhibitors for drug discovery programs targeting coagulation, cancer, and inflammatory diseases.
• Diagnostic Reagent Manufacturing: Serves as a key component in the formulation of clinical diagnostic kits for measuring proteolytic activity in biological samples.
• Quality Control in Biologics: Used to monitor and ensure the activity and consistency of enzyme preparations used in therapeutic production.

Basic Information

Product Name	Benzyloxycarbonyl-Glycyl-Glycyl-Arginine β-Naphthylamide
CAS No.	17278-97-6
Molecular Formula	C28H36N8O6
Molecular Weight	580.64 g/mol
Synonyms	Z-Gly-Gly-Arg-βNA; Z-Gly-Gly-Arg-2-Naphthylamide; Carbobenzoxy-Gly-Gly-Arg-β-Naphthylamide; Benzyloxycarbonylglycylglycyl-L-arginine 2-naphthylamide; CBZ-Gly-Gly-Arg-βNA; Substrate for Trypsin-like Proteases; Chromogenic Substrate 17278-97-6
EINECS	Contact for details

Quality Control

Our Benzyloxycarbonyl-Glycyl-Glycyl-Arginine β-Naphthylamide is produced and tested under stringent quality management systems. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and performance suitability for sensitive enzymatic assays. Certificates of Analysis (COA) detailing HPLC purity, spectral data (NMR, MS), and biological activity are provided to guarantee traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Specific Rotation	Contact for details
Solubility	Soluble in DMSO, DMF; slightly soluble in water
Biological Activity	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.