Description

4-Ethoxy-1,1,1-Trifluoro-3-Buten-2-One is a versatile fluorinated organic building block characterized by its reactive enone and trifluoromethyl functionalities. This compound is of significant value in advanced organic synthesis, particularly for introducing the trifluoromethyl group, which is a key motif in pharmaceuticals and agrochemicals for enhancing metabolic stability and lipophilicity. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex, fluorine-containing molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs) containing trifluoromethyl groups, such as antiviral or anticancer agents.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the CF3 group improves biological activity and environmental persistence.
• Material Science Research: Serves as a precursor for fluorinated polymers or liquid crystals with unique thermal and optical properties.
• Organic Synthesis Building Block: Employed in Michael additions, cycloadditions, and other C-C bond-forming reactions to create complex fluorinated scaffolds.
• Fluorine Chemistry R&D: Essential for academic and industrial research focused on developing new methodologies for incorporating fluorine into organic molecules.

Basic Information

Product Name	4-Ethoxy-1,1,1-Trifluoro-3-Buten-2-One
CAS No.	17129-06-5
Molecular Formula	C6H7F3O2
Molecular Weight	168.11 g/mol
Synonyms	1,1,1-Trifluoro-4-ethoxy-3-buten-2-one; 4-Ethoxy-1,1,1-trifluorobut-3-en-2-one; 4-Ethoxy-1,1,1-trifluoro-3-buten-2-one; Ethyl 1,1,1-trifluoroacetoacetate enol ether; 3-Buten-2-one, 4-ethoxy-1,1,1-trifluoro-; TFAA enol ethyl ether
EINECS	Contact for details

Quality Control

Our 4-Ethoxy-1,1,1-Trifluoro-3-Buten-2-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC/HPLC for purity and NMR/IR for structural confirmation, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its highly volatile nature and reactivity as a strong acid/organic solvent, keep away from heat, sparks, and incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.