Description

o-tert-Butyl-L-Serine Methyl Ester Hydrochloride is a protected amino acid derivative, specifically the methyl ester hydrochloride salt of O-tert-butyl-L-serine. This compound is a crucial chiral building block in the synthesis of complex peptides and pharmaceutical intermediates, offering enhanced stability and solubility for specific coupling reactions. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for peptide-based therapeutics.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) as a protected serine derivative to prevent side reactions.
• Bioconjugation: Serves as a building block for creating modified peptides or peptide-drug conjugates with specific functional properties.
• Chemical Biology Research: Employed in the study of protein structure-function relationships and the development of enzyme inhibitors.
• Catalyst Ligand Preparation: Can be utilized in the synthesis of chiral ligands for asymmetric catalysis.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	o-tert-Butyl-L-Serine Methyl Ester Hydrochloride
CAS No.	17114-97-5
Molecular Formula	C8H18ClNO3
Molecular Weight	211.69 g/mol
Synonyms	L-Serine, O-(1,1-dimethylethyl)-, methyl ester, hydrochloride (1:1); (2S)-2-Amino-3-[(2-methylpropan-2-yl)oxy]propanoic acid methyl ester hydrochloride; Methyl (2S)-2-amino-3-(tert-butoxy)propanoate hydrochloride; O-tert-Butyl-L-serine methyl ester HCl; O-t-Butyl-L-serine methyl ester hydrochloride; Methyl O-tert-butyl-L-serinate hydrochloride; (S)-Methyl 2-amino-3-(tert-butoxy)propanoate hydrochloride
EINECS	Contact for details

Quality Control

Our o-tert-Butyl-L-Serine Methyl Ester Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical research and development. A Certificate of Analysis (COA) detailing specific results for identity, purity, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.