Description

H-Tyr(Tbu)-Otbu Hcl CAS NO 17083-23-7 is a protected tyrosine derivative, specifically the tert-butyl ether of the phenolic hydroxyl group and the tert-butyl ester of the carboxylic acid, supplied as its hydrochloride salt. This compound is a crucial building block in solid-phase peptide synthesis (SPPS), enabling the controlled assembly of complex peptides by protecting reactive functional groups from side reactions. It is primarily needed by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in developing therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid derivative for the Fmoc/tBu strategy, facilitating the synthesis of tyrosine-containing peptides.
• Pharmaceutical Intermediate: Used in the research and development of novel peptide-based drugs, hormones, and enzyme inhibitors.
• Bioconjugation & Labeling: Serves as a precursor for introducing tyrosine residues into biomolecules for subsequent radioiodination or other modifications.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for high-throughput screening in drug discovery.
• Biochemical Research: Used in academic and industrial labs to study protein-protein interactions, enzyme mechanisms, and signal transduction pathways.
• Custom Peptide Service: A fundamental raw material for contract research organizations (CROs) and CDMOs offering custom peptide manufacturing services.

Basic Information

Product Name	H-Tyr(Tbu)-Otbu Hcl
CAS No.	17083-23-7
Molecular Formula	C₁₈H₂₉NO₄·HCl
Molecular Weight	359.89 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-O-tert-butyl-L-tyrosine; Boc-Tyr(tBu)-OH; L-Tyrosine, N-[(1,1-dimethylethoxy)carbonyl]-O-(1,1-dimethylethyl)-; Boc-L-Tyrosine(O-t-butyl); Boc-Tyr(tBu)-OtBu HCl; H-Tyr(O-tBu)-OtBu hydrochloride; N-Boc-O-t-butyl-L-tyrosine tert-butyl ester hydrochloride; Tyrosine derivative (protected)
EINECS	Contact for details

Quality Control

Our H-Tyr(Tbu)-Otbu Hcl is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric integrity, and NMR for structural confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥98.0%
Optical Rotation	-15.0° to -18.0° (c=1 in DMF)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.