Description

Z-Thr(Tbu)-Oh is a protected amino acid derivative, specifically the tert-butyl ether of Z-protected L-threonine. This compound is a crucial building block in solid-phase peptide synthesis (SPPS), where it provides orthogonal protection for the threonine side chain hydroxyl group. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require high-purity intermediates for the production of complex peptides, peptide hormones, and therapeutic agents.

Application

• Peptide Synthesis: A key protected intermediate in the solid-phase and solution-phase synthesis of complex peptides.
• Pharmaceutical Research: Used in the development and production of peptide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Bioconjugation: Serves as a modified amino acid for creating site-specifically labeled peptides for diagnostic or therapeutic purposes.
• Combinatorial Chemistry: Employed in libraries for drug discovery to explore structure-activity relationships (SAR).
• Biochemical Research: Used in studies of protein structure, function, and enzyme-substrate interactions.
• Production of Specialty Peptides: Critical for synthesizing peptides containing threonine residues that require selective side-chain deprotection.

Basic Information

Product Name	Z-Thr(Tbu)-Oh
CAS No.	16966-09-9
Molecular Formula	C₁₆H₂₃NO₅
Molecular Weight	309.36 g/mol
Synonyms	N-Carbobenzyloxy-O-tert-butyl-L-threonine; Z-O-tert-butyl-L-threonine; Nα-(Benzyloxycarbonyl)-O-tert-butyl-L-threonine; (2S,3R)-2-[[(Benzyloxy)carbonyl]amino]-3-[(2-methylpropan-2-yl)oxy]butanoic acid; Z-L-Threonine(tBu)-OH; Boc-Thr(tBu)-OH (common confusion, but incorrect for Z-protection); Cbz-Thr(tBu)-OH; N-Cbz-O-t-butyl-L-threonine
EINECS	Contact for details

Quality Control

Our Z-Thr(Tbu)-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and NMR for structural confirmation, to ensure it meets the stringent requirements for peptide synthesis. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Optical Rotation	[α]²⁰D = Specific range provided on COA
Chiral Purity	≥99.0% (by chiral HPLC)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.