Description

Boc-Lys(Tfa)-Oh CAS NO 16965-06-3 is a protected amino acid derivative, specifically Nα-Boc-Nε-trifluoroacetyl-L-lysine, serving as a crucial building block in solid-phase peptide synthesis (SPPS). This compound is essential for researchers and manufacturers requiring precise, orthogonal protection strategies for the lysine side chain, enabling the synthesis of complex peptides and bioconjugates. It is primarily utilized by pharmaceutical R&D teams, biotechnology companies, and fine chemical suppliers focused on developing therapeutic peptides, diagnostic agents, and advanced biomaterials.

Application

• Peptide Synthesis: A key intermediate in the Fmoc/t-Bu and Boc/Bzl strategies for the controlled incorporation of lysine residues.
• Pharmaceutical Research: Used in the development of peptide-based drugs, hormones, and enzyme inhibitors where selective deprotection is required.
• Bioconjugation: Serves as a precursor for creating labeled peptides or peptide-drug conjugates for targeted therapies.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to discover new bioactive compounds.
• Academic Research: Fundamental tool in biochemistry and molecular biology laboratories for studying protein structure and function.
• Fine Chemical Production: Intermediate in the multi-step synthesis of complex organic molecules and specialty chemicals.

Basic Information

Product Name	Boc-Lys(Tfa)-Oh
CAS No.	16965-06-3
Molecular Formula	C13H21F3N2O5
Molecular Weight	342.31 g/mol
Synonyms	Nα-Boc-Nε-trifluoroacetyl-L-lysine; (S)-2-((tert-Butoxycarbonyl)amino)-6-(2,2,2-trifluoroacetamido)hexanoic acid; Boc-Lys(TFA)-OH; Boc-Nε-TFA-L-lysine; Boc-Lys(Tfa)-OH; Nα-Boc-Nε-TFA-L-lysine; N-Boc-N'-TFA-L-lysine; BOC-LYS(TFA)-OH
EINECS	Contact for details

Quality Control

Our Boc-Lys(Tfa)-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and production applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic identification. Certificates of Analysis (COA) detailing all specifications are provided and available upon request, supporting compliance with cGMP and other relevant quality guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep the container tightly sealed in a desiccated environment when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.