Description

Boc-Val-Onp CAS NO 16948-40-6 is a protected amino acid derivative, specifically the p-nitrophenyl ester of N-tert-butoxycarbonyl-L-valine. This compound is a critical reagent in peptide synthesis, where it serves as an activated ester for the efficient and selective coupling of the valine residue. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel peptides, peptidomimetics, and active pharmaceutical ingredients (APIs). Its role is essential for constructing complex molecular architectures with high precision and yield.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an activated building block for the controlled incorporation of Boc-protected valine.
• Solution-Phase Peptide Synthesis: For the segment condensation or stepwise elongation of peptide chains in solution.
• Pharmaceutical Intermediate Manufacturing: In the production of peptide-based drug candidates and therapeutic agents.
• Bioconjugation Chemistry: For attaching valine or peptide sequences to other biomolecules, polymers, or surfaces.
• Organic Synthesis Research: As a specialized reagent for amide bond formation under mild conditions.
• Production of Custom Peptides: Used by CROs and CDMOs to synthesize specific peptide sequences for clients.

Basic Information

Product Name	Boc-Val-Onp
CAS No.	16948-40-6
Molecular Formula	C₁₆H₂₂N₂O₆
Molecular Weight	338.36 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-L-valine 4-nitrophenyl ester; Boc-L-valine 4-nitrophenyl ester; Boc-Val-ONp; N-Boc-L-valine p-nitrophenyl ester; (S)-2-((tert-Butoxycarbonyl)amino)-3-methylbutanoic acid 4-nitrophenyl ester; tert-Butyloxycarbonylvaline p-nitrophenyl ester; BOC-Val-ONP; BOC-L-Val-ONP
EINECS	Contact for details

Quality Control

Every batch of Boc-Val-Onp is manufactured and tested under strict quality management protocols to ensure consistency and reliability for sensitive synthetic applications. Our products undergo rigorous quality testing, including chiral purity and chemical purity analysis, to ensure compliance with industry standards. Certificates of Analysis (COA) detailing specific batch results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent decomposition. For long-term storage, consider using a desiccator.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Purity ([α]D)	Contact for details
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.