Description

Boc-Ser(Bzl)-Onp CAS NO 16948-39-3 is a protected serine derivative, specifically the p-nitrophenyl ester of N-tert-butoxycarbonyl-O-benzyl-L-serine, widely used as a key building block in peptide synthesis. This compound is crucial for researchers and manufacturers requiring controlled, high-fidelity coupling reactions to construct complex peptide sequences. It is primarily utilized by pharmaceutical R&D teams, biotech companies, and fine chemical suppliers engaged in the development of therapeutic peptides, peptidomimetics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): Employed as an activated ester for the efficient incorporation of serine with orthogonal side-chain protection into growing peptide chains.
• Solution-Phase Peptide Synthesis: Serves as a crucial coupling component for the fragment condensation approach in synthesizing longer or complex peptides.
• Pharmaceutical Intermediate: Acts as a key raw material in the research and production of active pharmaceutical ingredients (APIs) for peptide-based drugs.
• Bioconjugation and Probe Development: Used to introduce serine residues with specific protecting groups into molecules for creating labeled peptides or affinity probes.
• Academic and Industrial Research: Essential for synthetic chemistry and biochemistry laboratories exploring new peptide structures, functions, and modifications.
• Custom Peptide Service Providers: A staple reagent for CROs and CDMOs offering bespoke peptide manufacturing services to the global market.

Basic Information

Product Name	Boc-Ser(Bzl)-Onp
CAS No.	16948-39-3
Molecular Formula	C21H24N2O7
Molecular Weight	416.43 g/mol
Synonyms	N-α-(tert-Butoxycarbonyl)-O-benzyl-L-serine p-nitrophenyl ester; Boc-Ser(Bzl)-ONp; Boc-O-benzyl-L-serine 4-nitrophenyl ester; N-Boc-O-benzylserine p-nitrophenyl ester; tert-Butyloxycarbonyl-O-benzyl-L-serine p-nitrophenyl ester; (S)-2-((tert-Butoxycarbonyl)amino)-3-(benzyloxy)propanoic acid 4-nitrophenyl ester; Boc-Ser(Bzl)-OPnp; Boc-L-Ser(Bzl)-ONp
EINECS	Contact for details

Quality Control

Our Boc-Ser(Bzl)-Onp is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for peptide synthesis. Certificates of Analysis (COA) detailing identity, purity, and specific impurity profiles are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.