Description

Boc-n-Methyl-L-Alanine CAS NO 16948-16-6 is a protected amino acid derivative, specifically an N-methylated alanine with a tert-butoxycarbonyl (Boc) protecting group on the amine. This compound is a crucial building block in modern peptide synthesis, enabling the controlled introduction of N-methylated residues, which are key to enhancing peptide stability, membrane permeability, and biological activity. It is primarily utilized by pharmaceutical R&D teams, peptide manufacturers, and academic researchers developing novel therapeutic peptides and peptidomimetics.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for incorporating N-methyl-alanine residues into peptide chains to improve metabolic stability and bioavailability.
• Pharmaceutical Research: Used in the development of peptide-based drugs, including hormone analogs, enzyme inhibitors, and targeted therapeutics.
• Peptidomimetic Design: Serves as a scaffold for creating non-natural peptide analogs with enhanced pharmacological properties.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse compound libraries for high-throughput screening in drug discovery.
• Bioconjugation: Can be used to create modified peptides for conjugation with other molecules, such as dyes, drugs, or polymers.
• Academic & Industrial R&D: Fundamental research tool for studying peptide structure-activity relationships (SAR) and backbone modifications.

Basic Information

Product Name	Boc-n-Methyl-L-Alanine
CAS No.	16948-16-6
Molecular Formula	C9H17NO4
Molecular Weight	203.24 g/mol
Synonyms	(2S)-2-[(tert-Butoxycarbonyl)(methyl)amino]propanoic acid; N-(tert-Butoxycarbonyl)-N-methyl-L-alanine; Boc-N-Me-L-Ala-OH; Boc-N-Me-Ala-OH; N-Boc-N-methyl-L-alanine; Nα-Boc-Nα-methyl-L-alanine; N-(tert-Butoxycarbonyl)-N-methylalanine; BOC-N-METHYL-L-ALANINE
EINECS	Contact for details

Quality Control

Our Boc-n-Methyl-L-Alanine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for sensitive peptide synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring full traceability and compliance with research and cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.