Description

(S)-Boc-3-Amino-2-(p-Toluenesulfonylamino)-Propionic Acid is a high-purity, non-natural amino acid derivative featuring orthogonal protecting groups. This compound is a critical chiral building block for the synthesis of complex peptides and peptidomimetics, offering precise control over molecular architecture. It is essential for researchers and manufacturers in pharmaceutical development, particularly for creating novel active pharmaceutical ingredients (APIs) and advanced intermediates in medicinal chemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of peptide-based therapeutics and protease inhibitors.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to introduce specific, protected amino acid sequences with defined stereochemistry.
• Medicinal Chemistry Research: Serves as a constrained scaffold for constructing focused libraries in drug discovery programs targeting various diseases.
• Bioconjugation: Utilized in the preparation of chemically modified peptides for biochemical studies and the development of antibody-drug conjugates (ADCs).
• Process Chemistry: Employed in the scale-up and optimization of synthetic routes for GMP production of candidate drugs.

Basic Information

Product Name	(S)-Boc-3-Amino-2-(p-Toluenesulfonylamino)-Propionic Acid
CAS No.	16947-86-7
Molecular Formula	C15H22N2O6S
Molecular Weight	358.41 g/mol
Synonyms	(S)-2-((tert-Butoxycarbonyl)amino)-3-((4-methylphenyl)sulfonamido)propanoic acid; Boc-Dap(Ts)-OH; (S)-3-((tert-Butoxycarbonyl)amino)-2-tosylaminopropionic acid; Nα-Boc-Nβ-Tos-2,3-diaminopropionic acid; (S)-N-Boc-N'-Tos-diaminopropionic acid; Boc-Dpr(Tos)-OH; (2S)-2-[[(4-Methylphenyl)sulfonyl]amino]-3-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid
EINECS	Contact for details

Quality Control

Our (S)-Boc-3-Amino-2-(p-Toluenesulfonylamino)-Propionic Acid is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and NMR for structural confirmation, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) with full traceability are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep the container tightly sealed in a desiccated environment after opening.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.