Description

Boc-D-Leucine Monohydrate is a high-purity, protected amino acid derivative essential for advanced peptide synthesis and pharmaceutical research. Its primary value lies in providing a chiral building block with a tert-butoxycarbonyl (Boc) protecting group, which is crucial for preventing unwanted side reactions during solid-phase and solution-phase peptide assembly. This compound is critically needed by research institutions, pharmaceutical development labs, and fine chemical manufacturers focused on producing novel therapeutic peptides, peptidomimetics, and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex peptide-based drugs and APIs.
• Peptide Synthesis: Used in Solid-Phase Peptide Synthesis (SPPS) and solution-phase methods to incorporate D-leucine residues.
• Proteomics & Biochemical Research: Serves as a critical reagent for studying enzyme-substrate interactions and designing enzyme inhibitors.
• Asymmetric Synthesis: Employed as a starting material or auxiliary in the preparation of non-natural amino acids and chiral compounds.
• Combinatorial Chemistry: Utilized in libraries for drug discovery and high-throughput screening of bioactive molecules.
• Reference Standard: Acts as a certified reference material (CRM) for analytical method development and quality control in pharmaceutical analysis.

Basic Information

Product Name	Boc-D-Leucine Monohydrate
CAS No.	16937-99-8
Molecular Formula	C11H21NO4 • H2O
Molecular Weight	249.30 g/mol (Monohydrate)
Synonyms	(R)-2-((tert-Butoxycarbonyl)amino)-4-methylpentanoic acid monohydrate; D-Boc-Leucine Monohydrate; N-(tert-Butoxycarbonyl)-D-leucine Monohydrate; N-Boc-D-leucine Monohydrate; Boc-D-Leu-OH • H2O; (R)-2-[(2-Methylpropan-2-yl)oxycarbonylamino]-4-methylpentanoic acid monohydrate; BOC-D-LEU; tert-Butyloxycarbonyl-D-leucine Monohydrate
EINECS	Contact for details

Quality Control

Our Boc-D-Leucine Monohydrate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. Each lot undergoes comprehensive analytical testing, including HPLC for assay and purity, chiral purity analysis, and verification of water content. A detailed Certificate of Analysis (COA) documenting identity, purity, and specific impurities is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. For long-term storage, consider desiccants or a nitrogen atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.5%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Water Content (KF)	6.0% - 8.0% (Theoretical for monohydrate: ~7.2%)
Specific Rotation	Contact for details
Heavy Metals	<10 ppm
Residue on Ignition	<0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.